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Neuregulin-4 (NRG4) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553227

Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF- like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family.The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart,… More details

$335 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuregulin-4 (NRG4), Active Protein
Full Product Name
Human Neuregulin-4 Recombinant
Product Gene Name
NRG4 active protein
Product Synonym Names
egf; neuregulin; nrg4; nrg-4; heregulin; hrg
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant NRG4 was lyophilized from 0.2 µm filtered PBS solution pH 7.4
Purity/Purification
>96% as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
Recombinant human Neuregulin-4 EGF domain is a disulfide-linked monomeric protein consisting of 62 amino acid residue subunits. and migrates as an approximately 7 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
OMIM
610894
3D Structure
ModBase 3D Structure for Q8WWG1
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Host Note
Optimized DNA sequence encoding Human Neuregulin-4 EGF domain was expressed in Escherichia Coli.
Biological Activity:
Determined by ELISA, recombinant NRG4 coated plate (3ug/mL) to bind Anti NRG4 antibody.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Product Categories/Family for NRG4 active protein

Cytokines

Other Notes

Small volumes of NRG4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRG4 purchase

MBS553227 is an active protein targeting NRG4. Also known as Human Neuregulin-4 Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for NRG4. It may not necessarily be applicable to this product.

NCBI GI #
20070380
NCBI GeneID
145957
NCBI Accession #
NP_612640.1
UniProt Primary Accession #
Q8WWG1
UniProt Secondary Accession #
A6NIE8
UniProt Related Accession #
Q0P6N4; Q0P6N5; Q0P6N6; Q68D87; Q7Z663; Q8WWG1
GenBank Nucleotide #
NM_138573.3
NCBI Official Full Name
pro-neuregulin-4, membrane-bound isoform
UniProt Protein Name
Pro-neuregulin-4, membrane-bound isoform
Protein Family
Pro-neuregulin
UniProt Gene Name
NRG4
UniProt Synonym Gene Names
Pro-NRG4; NRG-4
UniProt Entry Name
NRG4_HUMAN

NCBI Summary for NRG4

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

UniProt Comments for NRG4

NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: extracellular space; integral to membrane; extracellular region; plasma membrane

Molecular Function: growth factor activity; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NRG4 active protein

 Reference Product  PubMed Publications
 ERBB4 active protein  >5 publications with NRG4 and ERBB4

Pathways associated with NRG4 active protein

 Products by Pathway  Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram

Diseases associated with NRG4 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with NRG4 and Neoplasms
 Breast Neoplasms Antibodies  >5 publications with NRG4 and Breast Neoplasms
 Carcinoma Antibodies  >2 publications with NRG4 and Carcinoma
 Prostatic Neoplasms Antibodies  >1 publications with NRG4 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with NRG4 and Neoplasms, Experimental
 Urinary Bladder Neoplasms Antibodies  >1 publications with NRG4 and Urinary Bladder Neoplasms
 Esophageal Neoplasms Antibodies  >1 publications with NRG4 and Esophageal Neoplasms
 Liver Neoplasms Antibodies  >1 publications with NRG4 and Liver Neoplasms

Organs/Tissues associated with NRG4 active protein

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with NRG4 and Prostate
 Liver Antibodies  >1 publications with NRG4 and Liver
 Bladder Antibodies  >1 publications with NRG4 and Bladder
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