• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Il-11 Receptor Alpha (IL11RA) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553276

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic… More details

$335 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-11 receptor alpha (IL11RA), Active Protein
Full Product Name
Mouse IL-11 receptor alpha Recombinant
Product Gene Name
IL11RA active protein
Product Synonym Gene Name
IL-11
Product Synonym Names
IL-11RA; IL11ra
Host
HEK Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant mouse Interleukin-11 alpha was lyophilized from a 0.2um filtered PBS solution pH 7.4.
Purity/Purification
>85%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
Recombinant Mouse Interleukin-11RA is a monomer consisting of 355 amino acid residue subunits, and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE.
3D Structure
ModBase 3D Structure for Q64385
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Source
Mouse
Source Note
DNA sequence encoding extracellular domain of Mouse IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells.
Biological Activity
The activity was determined by its ability to bind mouse IL-6ST in functional ELISA.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Product Categories/Family for IL11RA active protein

Receptors CD

Other Notes

Small volumes of IL11RA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL11RA purchase

MBS553276 is an active protein targeting IL11RA. Also known as Mouse IL-11 receptor alpha Recombinant. Host: HEK Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL11RA. It may not necessarily be applicable to this product.

NCBI GI #
254281269
NCBI GeneID
16157
NCBI Accession #
NP_001156873.1
UniProt Primary Accession #
Q64385
UniProt Secondary Accession #
Q6NSQ0; A2AMS4
GenBank Nucleotide #
NM_001163401.1
NCBI Official Full Name
interleukin-11 receptor subunit alpha-1
UniProt Protein Name
Interleukin-11 receptor subunit alpha-1
UniProt Synonym Protein Names
Enhancer trap locus homolog 2; Etl-2; Novel cytokine receptor 1
Protein Family
Interleukin-11 receptor
UniProt Gene Name
Il11ra1
UniProt Synonym Gene Names
Etl2; Il11ra; IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; Etl-2; NR-1; NR1
UniProt Entry Name
I11RA_MOUSE

UniProt Comments for IL11RA

IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: interleukin-11 binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 receptor activity

Biological Process: maternal process involved in pregnancy; natural killer cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; decidualization; placenta development
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000