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Defensin 5 (DEFA5) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555010

Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Defensin 5 (DEFA5), Antibody
Full Product Name
Defensin 5, Monoclonal, Mouse
Product Gene Name
Species Reactivity
Human
Form/Format
Ascites Fluid - Liquid
Molecular Weight
10,071 Da
OMIM
600472
Type Info
Rabbit IgG
Immunogen
Full-length proHD5 protein. [Swiss-Prot# Q01523] The propeptide is the full-length protein. In the mature form, it is cleaved at residue 63 (alanine).

Product Categories/Family for anti-DEFA5 antibody

Applications Tested/Suitable for anti-DEFA5 antibody
Immunohistochemistry (IHC)

Testing Data of anti-DEFA5 antibody

Image: Defensin 5 staining of Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining.
Anti-DEFA5 Antibody – Cat# MBS555010

Other Notes

Small volumes of anti-DEFA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEFA5 purchase

MBS555010 is an antibody targeting DEFA5. Also known as Defensin 5, Monoclonal, Mouse. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for DEFA5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
defensin-5 preproprotein
NCBI Official Synonym Full Names
defensin alpha 5
NCBI Official Symbol
DEFA5
NCBI Official Synonym Symbols
DEF5; HD-5
UniProt Protein Name
Defensin-5
UniProt Synonym Protein Names
Defensin, alpha 5; HD5(20-94)
Protein Family
UniProt Gene Name
DEFA5
UniProt Synonym Gene Names
DEF5
UniProt Entry Name
DEF5_HUMAN
NCBI Protein Information
defensin-5

NCBI Summary for DEFA5

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Jul 2008]
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UniProt Comments for DEFA5

DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region

Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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