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5-Ht (Serotonin) 1a (5HT1A R) Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555178

MBS555178 is an antibody targeting 5HT1A R. Also known as 5-HT (Serotonin) 1A Receptor Antibody, Rabbit. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$720 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
5-HT (Serotonin) 1A (5HT1A R), Antibody
Full Product Name
5-HT (Serotonin) 1A Receptor Antibody, Rabbit
Product Gene Name
anti-5HT1A R antibody
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified - 100ul of affinity ourified serum containing 1% BSA
Preparation and Storage
Store at 4-8 degrees
OMIM
109760
Immunogen
synthetic peptide sequence corresponding to amino acids 294-312 of the rat 5-HT1A receptor

Product Categories/Family for anti-5HT1A R antibody

Antibodies; 5HT-Serotonins; 5HT (Serotonin) 1A Receptor; 5HT1A R
Applications Tested/Suitable for anti-5HT1A R antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-5HT1A R antibody
Western Blot: Analysis using rat brain extracts of cortex, hypothalamus, midbrain, and hindbrain, the antibody specifically labels a single band. Immunolabeling is completely abolished by pre-adsorption with synthetic rat 5HT transporter (579-599).

Immunohistochemistry: 1:200 – 1:400 using indirect immunofluorescence 1:200-1:600 using biotin/streptavidin HRP technique in rat raphe nuclei, hypothalamus, cortex, and spinal cord.

Additional notes for IHC: Antigen: rat 5-HT1A receptor (294-312) coupled to bovine thyroglobulin with glutaraldehyde.
Control Tissue: Rat cortex, hippocampus. Perfusion Fixation: 4% paraformaldehyde in 0.1M Phosphate buffer, pH 7.4; 500 mL over approximately 20 minutes.
Note: If needed, low levels of glutaraldehyde (0.1 - 0.3%) may be used in conjunction with paraformaldehyde. Sections: 50 ?m vibratome.
Antibody Dilution: 1/300 - 1/500 in PBS - Bn-SA/HRP detection Note: Use of Triton X-100 or other detergents is not recommended. Incubation on Tissue: 16 hours at 4°C
Detection System: Bn-SA/HRP - Use biotin-streptavidin/HRP at dilutions recommended by the manufacturer.

Other Notes

Small volumes of anti-5HT1A R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 5HT1A R. It may not necessarily be applicable to this product.

NCBI GI #
55956923
NCBI GeneID
3350
NCBI Accession #
NP_000515.2
UniProt Secondary Accession #
Q6LAE7
UniProt Related Accession #
P08908
GenBank Nucleotide #
NM_000524.3
NCBI Official Full Name
5-hydroxytryptamine receptor 1A
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 1A
NCBI Official Symbol
HTR1A
NCBI Official Synonym Symbols
G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
UniProt Protein Name
5-hydroxytryptamine receptor 1A
UniProt Synonym Protein Names
G-21; Serotonin receptor 1A
UniProt Gene Name
HTR1A
UniProt Synonym Gene Names
ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A
UniProt Entry Name
5HT1A_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 1A

UniProt Comments for 5HT1A R

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: dendrite; integral to plasma membrane; plasma membrane

Molecular Function: neurotransmitter receptor activity; protein binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; synaptic transmission

Disease: Periodic Fever, Menstrual Cycle-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-5HT1A R antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with anti-5HT1A R antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >101 publications with 5HT1A R and Mental Disorders
 Mood Disorders Antibodies  >56 publications with 5HT1A R and Mood Disorders
 Depressive Disorder Antibodies  >55 publications with 5HT1A R and Depressive Disorder
 Depressive Disorder, Major Antibodies  >47 publications with 5HT1A R and Depressive Disorder, Major
 Anxiety Disorders Antibodies  >30 publications with 5HT1A R and Anxiety Disorders
 Bipolar Disorder Antibodies  >12 publications with 5HT1A R and Bipolar Disorder
 Personality Disorders Antibodies  >9 publications with 5HT1A R and Personality Disorders
 Pain Antibodies  >6 publications with 5HT1A R and Pain
 Cognition Disorders Antibodies  >3 publications with 5HT1A R and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >3 publications with 5HT1A R and Neurobehavioral Manifestations

Organs/Tissues associated with anti-5HT1A R antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >83 publications with 5HT1A R and Brain
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