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CPT1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242457

Immunohistochemistry: MBS22457 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody,… More details

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Product Overview

Online Datasheet in PDF
Product Name
CPT1 / CPT1A, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human CPT1 / CPT1A
Product Gene Name
anti-CPT1 antibody
Product Synonym Gene Name
CPT1A
Product Synonym Names
Anti-CPT1 / CPT1A Antibody (Internal) IHC-plus; CPT1A; CPT1; CPT1-L; CPT I; CPTI-L; L-CPT1; Human CPT1; CPT1A
Clonality
Polyclonal
Host
Goat
Form/Format
TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CPT1A. This antibody is expected to recognize both reported isoforms (NP_001867.2; NP_001027017.1) but is not expected to recognise CPT1B.
Preparation and Storage
Aliquot and store at -20°C. Avoid freeze-thaw.
OMIM
phenotype 600528
3D Structure
ModBase 3D Structure for P50416
Target
CPT1A
Immunogen
CPT1A antibody was raised against peptide with C-DPAQTVEQRLKLFK, from the internal region of the protein sequence according to (NP_001867.2NP_001027017.1).
Immunogen Species
CPT1A antibody was raised against human
Epitope
aa621-634
Applications Tested/Suitable for anti-CPT1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Peptide-Enzyme-Linked Immunoabsorbent Assay
Application Notes for anti-CPT1 antibody
IHC-P (4 ug/ml)
WB (0.1 - 0.3 ug/ml)
Peptide-Enzyme-Linked Immunoabsorbent Assay (1:128000)

Optimal dilution to be determined by the researcher.

Immunohistochemistry (IHC) of anti-CPT1 antibody

Anti-CPT1A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Goat Anti-CPT1 Polyclonal Antibody – Cat# MBS242457

Immunohistochemistry (IHC) of anti-CPT1 antibody

Anti-CPT1A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Goat Anti-CPT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242457

Other Notes

Small volumes of anti-CPT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPT1 purchase

MBS242457 is an antibody targeting CPT1. Also known as Goat Polyclonal to Human CPT1 / CPT1A. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for CPT1. It may not necessarily be applicable to this product.

NCBI GI #
73623030
NCBI GeneID
1374
NCBI Accession #
NP_001867.2
UniProt Primary Accession #
P50416
UniProt Secondary Accession #
Q8TCU0; Q9BWK0
UniProt Related Accession #
P50416
GenBank Nucleotide #
NM_001876.3
NCBI Official Full Name
carnitine O-palmitoyltransferase 1, liver isoform isoform 1
NCBI Official Synonym Full Names
carnitine palmitoyltransferase 1A (liver)
NCBI Official Symbol
CPT1A
NCBI Official Synonym Symbols
CPT1; CPT1-L; L-CPT1
UniProt Protein Name
Carnitine O-palmitoyltransferase 1, liver isoform
UniProt Synonym Protein Names
Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A
Protein Family
Cholinephosphotransferase
UniProt Gene Name
CPT1A
UniProt Synonym Gene Names
CPT1; CPT1-L; CPT I; CPTI-L
UniProt Entry Name
CPT1A_HUMAN
NCBI Protein Information
carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform

NCBI Summary for CPT1

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CPT1

CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Lipid Metabolism - fatty acid; EC 2.3.1.21; Transferase; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane

Molecular Function: identical protein binding; carnitine O-palmitoyltransferase activity

Biological Process: response to drug; circadian rhythm; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; triacylglycerol metabolic process; fatty acid beta-oxidation; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Carnitine Palmitoyltransferase I Deficiency
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Research Articles on CPT1

1. The results suggest the generality of carnitine palmitoyltransferase-1 inhibition under various stress conditions associated with ROS generation, providing an insight into a mechanism for oxidative dysfunction in mitochondrial metabolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CPT1 antibody

 Reference Product  PubMed Publications
 ACOX1 antibody  >14 publications with CPT1 and ACOX1
 PPARA antibody  >9 publications with CPT1 and PPARA
 ACADVL antibody  >8 publications with CPT1 and ACADVL
 PPARGC1A antibody  >7 publications with CPT1 and PPARGC1A
 ACSL1 antibody  >7 publications with CPT1 and ACSL1
 ACADM antibody  >3 publications with CPT1 and ACADM
 ACADL antibody  >2 publications with CPT1 and ACADL
 RXRA antibody  >1 publications with CPT1 and RXRA
 ACACB antibody  >1 publications with CPT1 and ACACB

Pathways associated with anti-CPT1 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram

Diseases associated with anti-CPT1 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >91 publications with CPT1 and Fatty Liver
 Liver Diseases Antibodies  >40 publications with CPT1 and Liver Diseases
 Insulin Resistance Antibodies  >32 publications with CPT1 and Insulin Resistance
 Inflammation Antibodies  >14 publications with CPT1 and Inflammation
 Cardiovascular Diseases Antibodies  >8 publications with CPT1 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >8 publications with CPT1 and Dyslipidemias
 Atherosclerosis Antibodies  >8 publications with CPT1 and Atherosclerosis
 Diabetes Mellitus Antibodies  >7 publications with CPT1 and Diabetes Mellitus
 Hepatitis Antibodies  >7 publications with CPT1 and Hepatitis
 Weight Gain Antibodies  >7 publications with CPT1 and Weight Gain

Organs/Tissues associated with anti-CPT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >116 publications with CPT1 and Liver
 Blood Antibodies  >62 publications with CPT1 and Blood
 Muscle Antibodies  >42 publications with CPT1 and Muscle
 Brain Antibodies  >17 publications with CPT1 and Brain
 Kidney Antibodies  >9 publications with CPT1 and Kidney
 Connective Tissue Antibodies  >8 publications with CPT1 and Connective Tissue
 Thyroid Antibodies  >5 publications with CPT1 and Thyroid
 Pancreas Antibodies  >5 publications with CPT1 and Pancreas
 Vascular Antibodies  >4 publications with CPT1 and Vascular
 Bone Antibodies  >3 publications with CPT1 and Bone
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