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TRIM2 Antibody – Goat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555931

TRIM RING finger protein TRIM2, a ubiquitin ligase, is highly expressed in the nervous system. It binds to neurofilament light subunit (NF-L);and regulates NF-L ubiquitination. Deficiencies in TRIM2 increases NF-L level in axons and NF-L-filled axonal… More details

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Product Overview

Product Name
TRIM2, Antibody
Full Product Name
TRIM2
Product Gene Name
Isotype
IgG
Host
Goat
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purified
OMIM
gene 615490
3D Structure
ModBase 3D Structure for Q9C040
Immunogen
Peptide with sequence DSGNHCFKVYRYLQ, from the C Terminus of the TRIM2 protein sequence according to NP_056086.2; NP_001123539.1
Applications Tested/Suitable for anti-TRIM2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-TRIM2 antibody

TRIM2 (dilution: 6.3 ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.
Goat Anti-TRIM2 Antibody – Cat# MBS555931

Immunohistochemistry (IHC) of anti-TRIM2 antibody

TRIM2 (dilution: 0.5 ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-TRIM2 Antibody, Immunohistochemistry (IHC) – Cat# MBS555931

Other Notes

Small volumes of anti-TRIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM2 purchase

MBS555931 is an antibody targeting TRIM2. Reactive in Human, Mouse, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tripartite motif-containing protein 2 isoform 1
NCBI Official Synonym Full Names
tripartite motif containing 2
NCBI Official Symbol
TRIM2
NCBI Official Synonym Symbols
CMT2R; RNF86
UniProt Protein Name
Tripartite motif-containing protein 2
UniProt Synonym Protein Names
E3 ubiquitin-protein ligase TRIM2; RING finger protein 86
UniProt Gene Name
TRIM2
UniProt Synonym Gene Names
KIAA0517; RNF86
UniProt Entry Name
TRIM2_HUMAN
NCBI Protein Information
tripartite motif-containing protein 2

NCBI Summary for TRIM2

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
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UniProt Comments for TRIM2

TRIM2: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Belongs to the TRIM/RBCC family.

Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: cytoplasm

Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: regulation of neuron apoptosis; protein ubiquitination

Disease: Charcot-marie-tooth Disease, Axonal, Type 2r
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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