Serotonin Receptor 5ht1a (HTR1A) Antibody – Rabbit Polyclonal

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine found in the central nervous system, gastrointestinal tract, and blood with broad physiological functions as a neurotransmitter, in gastric motility, hemostasis, and cardiovascular integrity. Seven subclasses (5-HT 1-7) of serotonin receptors have been identified, a majority of which are members of the seven transmembrane domain-containing G-protein coupled receptor (GPCR) family, and are the target of several anti-depressant drugs. The 5-HT1 subclass consists of five highly homologous receptors that couple via G(i/o) alpha subunits to inhibit adenylyl cyclase activity. The 5-HT1A receptor gene is 99% homologous between human and mouse, and is expressed from an intronless gene with a predicted length of 421 amino acids. 5-HT1A receptor activation is generally inhibitory to cAMP production, but may also stimulate type II adenylyl cyclase activity in a cell-specific manner via release of G(beta/gamma) subunits when coupled to G(i2). 5-HT1A expression in mammals is strongest in CNS limbic pathways that control emotion, including tissue of the hippocampus, dorsal raphé, and septum.

Small volumes of anti-Htr1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS565842 is an antibody targeting Htr1a. Also known as Serotonin receptor 5HT1A polyclonal antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.