PIDD Antibody – Mouse Monoclonal

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

PIDD: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. 7 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi apparatus; cytoplasm; nucleus

Molecular Function: protein binding; death receptor binding

Biological Process: caspase activation; positive regulation of apoptosis; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to DNA damage stimulus; negative regulation of apoptosis; activation of NF-kappaB transcription factor