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BMP-2 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS567211

BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily or structurally related signaling proteins. Bone morphogenic protein induces bone and cartilage formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia… More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BMP-2, Active Protein
Full Product Name
BMP-2 (human), (recombinant)
Product Gene Name
Host
HEK293 cells
Form/Format
White powder. Lyophilized from 1mg/mL in 1X PBS
Purity/Purification
>=95% (SDS-PAGE)
Sterile filtered
Preparation and Storage
For long term storage, store at -20 degree C
The reconstituted solution can be stored at 4 degree C for 1 week
After reconstitution, prepare aliquots and store at -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% BSA or serum)
OMIM
112261
3D Structure
ModBase 3D Structure for P12643
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Source Note
Glycosylated disulfide-linked homodimer
Reconstitution
Reconstitute with sterile 4 mM HCl containing 0.1% endotoxin-free recombinant HAS
Specific Activity
The specific activity was <=60ng/mL as determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Other Notes

Small volumes of BMP-2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-2 purchase

MBS567211 is an active protein targeting BMP-2. Also known as BMP-2 (human), (recombinant). Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Bone morphogenetic protein 2
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
BMP2
NCBI Official Synonym Symbols
BDA2; BMP2A
UniProt Protein Name
Bone morphogenetic protein 2
UniProt Synonym Protein Names
Bone morphogenetic protein 2A; BMP-2A
UniProt Gene Name
BMP2
UniProt Synonym Gene Names
BMP2A; BMP-2; BMP-2A
UniProt Entry Name
BMP2_HUMAN
NCBI Protein Information
bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A

NCBI Summary for BMP-2

The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP-2

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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