Vitronectin Receptor (CD51) Antibody – Mouse Monoclonal

CD51 (Cluster of Differentiation 51), known as vitronectin receptor alpha chain, or integrin alphaV is a type I integral membrane glycoprotein. CD51 forms a heterodimer with integrin beta1 (CD29), beta3 (CD61), beta5, beta6, or beta8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its beta chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.

Nesbitt, S., et al., 1993. J. Biol. Chem. 268:16737. Zola, H., et al., 2007. Leukocyte and Stromal Cell Molecules: The CD Markers Wiley-Liss A John Wiley & Sons, Inc., PubliCation J.M.W. Quinn, N.A. Athanasou, and J.O'D McGee,1991. Histochemistry, 96:169-176

Small volumes of anti-vitronectin receptor (CD51) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570190 is an antibody targeting vitronectin receptor (CD51). Also known as Mouse anti Human vitronectin receptor (CD51). Reactive in Human. Host: Mouse (Balb/c).