Mouse Anti-psmA Monoclonal Antibody – Cat# MBS570213

Figure 1: Immunofluorescent staining of LNCaP cells

psmA Antibody – Mouse Monoclonal

Name: psmA Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS570213
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS570213

Prostate specific antigen (PSA) is the most widely used marker of prostate cancer. Immunoassays for PSA using monoclonal (MAb) or polyclonal antibodies have clinical appliCations, such as monitoring and early detection of prostate cancer. However, PSA is not… More details

$605 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSMA, Monoclonal Antibody

Full Product Name

Mouse anti PSMA

Product Gene Name

anti-psmA antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

107.1A4

Host

Mouse

Species Reactivity

Human

Form/Format

Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.

Specificity

107.1A4 recognizes an antigen, which appeared to be distinct from those previously described and shows specific tumor targeting in preliminary in vivo studies. MAb 107-1A4 is suggested to recognize a distinct conformational and unique epitope in the extracellular domain of PSMA. PSMA is a type II membrane glycoprotein of 100kDa that has a short intracellular N-terminal domain (residues 1 to 18), a transmembrane region (residues 19 to 43) and a large extracellular domain consisting of residues 44 to 750.

Preparation and Storage

The antibody is shipped at ambient temperature and may be stored at +4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at +4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.

Chromosome Location

NC_007681.1 (1416315..1417178)

Source Note

107.1A4 is a Mouse monoclonal IgG1/k antibody derived by fusion of SP2/0-Ag14 Mouse myeloma cells with spleen cells from an immunized Mouse, using a two-phase immunization protocol involving the prostate cancer cell line LNCaP.

Product Type

Primary Antibodies

Product Categories/Family for anti-psmA antibody

Membrane; Tumour marker

Applications Tested/Suitable for anti-psmA antibody

ELISA (EIA), Flow Cytometry (FC), Immunocytochemistry (IHC), Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin)

Application Notes for anti-psmA antibody

MAb 107-1A4 could not be used in Western blot, is useful for immunohistochemistry on frozen and paraffin-embedded tissues, immunocytochemistry, flow cytometry and ELISA. Optimal antibody dilution should be determined by titRation; recommended range is 1:100 - 1:1000 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent.

Product References and Citations for anti-psmA antibody

Brown, L.G., Wegner, S.K., Wang, H., Buhler, K.R., Arfman, E.W., Lange, P.H. and Vesella,. (1998). A novel monoclonal antibody 107-1A4 with high prostate specificity: geneRation, characterization of antigen expression, and targeting of Human prostate cancer xenografts. Prostate Cancer Prostatic Dis. 1, 208-15.Wang, S., Diamond, D.L., Hass, G.M., Sokoloff, R. and Vesella, R.L. (2001). IdentifiCation of prostate specific membrane antigen (PSMA) as the target of monoclonal antibody 107-1A4 by proteinchip; array, surface-enhanced laser desorption/ionization (SELDI) technology. Int J Cancer 92, 871-6.

Other Notes

Small volumes of anti-psmA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for psmA purchase

MBS570213 is an antibody targeting psmA. Also known as Mouse anti PSMA. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for psmA. It may not necessarily be applicable to this product.

NCBI GI #

84373355

NCBI GeneID

3855492

NCBI Accession #

ABC57625.1

NCBI Official Full Name

PsmA

NCBI Official Symbol

psmA

NCBI Protein Information

proteasome complex, subunit alpha; proteasome subunit alpha

UniProt Comments for psmA

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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