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ARID2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120131

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the… More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARID2, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human ARID2
Product Gene Name
anti-ARID2 antibody
Product Synonym Names
Homo sapiens AT rich interactive domain 2 (ARID, RFX-like) (ARID2); p200; BAF200; FLJ30619; KIAA1557; DKFZp686G052;DKFZp779P0222
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2036C1a
Host
Mouse
Species Reactivity
Human
Form/Format
Mouse monoclonal anti-human ARID2 antibody in PBS (3.0 mM KCl, 1.5 mM KH PO , 140 mM NaCl, 8.0 mM Na HPO (pH 7.4)) containing 1% bovine serum albumin (BSA)and 0.05% sodium azide (NaN ).
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation and Storage
Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.
Molecular Weight
197 kDa
OMIM
609539
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Disposal
This antibody solution contains sodium azide (NaN )as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-ARID2 antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-ARID2 antibody
WB:02-2ug/ml
ICC: 2-100ug/ml

Quality Control of anti-ARID2 antibody

Western blot analysis of immunized recombinant protein, using anti-ARID2 monoclonal antibody.
Mouse Anti-ARID2 Monoclonal Antibody – Cat# MBS120131

Quality Control #2 of anti-ARID2 antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-ARID2 Monoclonal Antibody, Quality Control #2 – Cat# MBS120131

Western Blot of anti-ARID2 antibody

Detection of ARlD2 by Western blot.
Samples: Whole cell lysate from human HeLa (H. 50ug) , mouse NIH3T3 (M, 50ug) and rat F2408 CR, 50ug) cells.
Mouse Anti-ARID2 Monoclonal Antibody, Western Blot – Cat# MBS120131

Immunostaining of anti-ARID2 antibody

lmmunostaining analysis in l-IeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-1OO in PBS. The cells were immunostained with anti-ARlD2 mAb.
Mouse Anti-ARID2 Monoclonal Antibody, Immunostaining – Cat# MBS120131

Other Notes

Small volumes of anti-ARID2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARID2 purchase

MBS120131 is an antibody targeting ARID2. Also known as Mouse monoclonal antibody Anti-Human ARID2. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ARID2. It may not necessarily be applicable to this product.

NCBI GI #
56549667
NCBI GeneID
196528
NCBI Accession #
NP_689854.2
UniProt Secondary Accession #
Q15KG9; Q5EB51; Q645I3; Q6ZRY5; Q7Z3I5; Q86T28; Q96SJ6; Q9HCL5
UniProt Related Accession #
Q68CP9
GenBank Nucleotide #
NM_152641
NCBI Official Full Name
Homo sapiens AT rich interactive domain 2 (ARID, RFX-like) (ARID2), mRNA
NCBI Official Synonym Full Names
AT rich interactive domain 2 (ARID, RFX-like)
NCBI Official Symbol
ARID2
NCBI Official Synonym Symbols
p200; BAF200
UniProt Protein Name
AT-rich interactive domain-containing protein 2
UniProt Synonym Protein Names
BRG1-associated factor 200; BAF200; Zinc finger protein with activation potential; Zipzap/p200
Protein Family
AT-rich interactive domain-containing protein
UniProt Gene Name
ARID2
UniProt Entry Name
ARID2_HUMAN
NCBI Protein Information
AT-rich interactive domain-containing protein 2; ARID domain-containing protein 2; BRG1-associated factor 200; zinc finger protein with activation potential; zipzap; zipzap/p200

NCBI Summary for ARID2

ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]

UniProt Comments for ARID2

ARID2: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: nucleoplasm; plasma membrane

Molecular Function: protein binding; DNA binding; metal ion binding

Biological Process: nucleosome disassembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
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Research Articles on ARID2

1. Mutations in ARID2 gene is associated with microsatellite unstable colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARID2 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram

Diseases associated with anti-ARID2 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >10 publications with ARID2 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >9 publications with ARID2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >8 publications with ARID2 and Liver Neoplasms
 Lung Neoplasms Antibodies  >3 publications with ARID2 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with ARID2 and Ovarian Neoplasms
 Kidney Diseases Antibodies  >2 publications with ARID2 and Kidney Diseases
 Skin Neoplasms Antibodies  >1 publications with ARID2 and Skin Neoplasms
 Fibrosis Antibodies  >1 publications with ARID2 and Fibrosis
 Inflammation Antibodies  >1 publications with ARID2 and Inflammation

Organs/Tissues associated with anti-ARID2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with ARID2 and Liver
 Lung Antibodies  >4 publications with ARID2 and Lung
 Kidney Antibodies  >3 publications with ARID2 and Kidney
 Heart Antibodies  >2 publications with ARID2 and Heart
 Muscle Antibodies  >1 publications with ARID2 and Muscle
 Skin Antibodies  >1 publications with ARID2 and Skin
 Mouth Antibodies  >1 publications with ARID2 and Mouth
 Embryonic Tissue Antibodies  >1 publications with ARID2 and Embryonic Tissue
 Bladder Antibodies  >1 publications with ARID2 and Bladder
 Brain Antibodies  >1 publications with ARID2 and Brain
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