Myeloperoxidase (MPO) Antibody – Mouse

Myeloperoxidase (MPO) is a glycoprotein present in the azurophil (primary) granules of myeloid cells, which appears in the myeloblast stage of myeloid cell differentiation. MPO is he most common functional protein of myeloid cells and is involved in the inflammatory response. It helps to kill microbes by breaking down peroxide in the presence of halide ions, contributing to the bactericidal function of granulocytes. The primary translation product of MPO undergoes glycosylation with production of the 89 kDa heme-free apopro-MPO form followed by incorporation of heme and conversion into the enzymatically active pro-MPO form. Subsequently, pro-MPO becomes targeted to azurophil granules where final processing occurs to produce mature dimeric MPO consisting of the 59-64 kDa MPO alpha-chain and the 14 kDa MPO beta-chain.

The MPO-C2 mAb (clone 8E6) recognizes virtually all myelomonocytic cells including AML blasts. The MPO-C2 mAb permits the identification and enumeration of myeloid cells in normal and malignant human blood and bone marrow using flow cytometry. Results must be put within the context of other tests as well as the clinical history of the patient by a certified professional before final interpretation. Analysis performed with this antibody should be paralleled by positive and negative controls.

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Small volumes of anti-MPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570353 is an antibody targeting MPO. Also known as Mouse anti Myeloperoxidase (MPO), conjugated to PE. Reactive in Human. Host: Mouse.