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1,5-Isoquinolinediol Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751062

1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 uM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol has been used to study the role of PARP1… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
1,5-Isoquinolinediol, Inhibitor
Full Product Name
1,5-Isoquinolinediol
Product Synonym Names
PARP inhibitor
Form/Format
POWDER
Purity/Purification
98.00%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
161.16
CAS Number
1188540
Formula
C9H7NO2
Smiles
Oc1cccc2c1cc[nH]c2=O
Solubility
DMSO: 20 mg/mL; Ethanol: 20 mg/mL; Water: 1 mg/mL
Pathways
Chromatin; Epigenetic
Receptor
PARP1
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Product References and Citations for 1,5-Isoquinolinediol, inhibitor

1. Davar D, et al. Role of PARP inhibitors in cancer biology and therapy.[J]. Current Medicinal Chemistry, 2012, 19(23).

Other Notes

Small volumes of 1,5-Isoquinolinediol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 1,5-Isoquinolinediol purchase

MBS5751062 is an inhibitor targeting 1,5-Isoquinolinediol.
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