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NVP-BSK805 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751513

MBS5751513 is an inhibitor targeting NVP-BSK805. NVP-BSK805 is an ATP-competitive JAK2 inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NVP-BSK805, Inhibitor
Full Product Name
NVP-BSK805
Product Gene Name
NVP-BSK805, inhibitor
Product Synonym Names
BSK 805; NVP-BSK805 2HCl
Form/Format
Powder
Purity/Purification
98.8%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
490.54
Formula
C27H28F2N6O
CAS
1092499-93-8
Smiles
Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1
Receptor (IC50)
JAK1: 31.63nM
JAK2: ~0.5nM
JAK3: 18.68nM
Tyk2: 10.76nM
JAK2 JH1: 0.48nM
FL JAK2 V617F: 0.56nM
FL JAK2 wt: 0.58nM
TYK2 JH1: 10.76nM
JAK3 JH1: 18.68nM
JAK1 JH1: 31.63nM
Solubility
DMSO: 10mMEthanol: 15mg/mL (26.62mM)
Water: 3mg/mL (5.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for NVP-BSK805, inhibitor

Home; Angiogenesis; JAK

Structure of NVP-BSK805, inhibitor

NVP-BSK805 Inhibitor – Cat# MBS5751513

Product References and Citations for NVP-BSK805, inhibitor

1. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490 (4):1176-1182.
2. Rubert J, et al. BMC Cancer, 2011, Jan (19), 11-24.
3. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9 (7):1945-55.

Other Notes

Small volumes of NVP-BSK805, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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