BRL50481 Inhibitor – BRL 50481

Name: BRL50481 Inhibitor; BRL 50481; MyBioSource
Brand: MyBioSource
SKU: MBS5751567
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751567

BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490uM for PDE7A, PDE7B, PDE4 and PDE3, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BRL 50481 (BRL50481), Inhibitor

Full Product Name

BRL 50481

Product Gene Name

BRL50481, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

244.27

Formula

C9H12N2O4S

CAS

433695-36-4

Smiles

CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O

Receptor (IC50)

PDE7A: 0.15uM
PDE7B: 12uM
PDE4: 62uM
PDE3: 490uM

Solubility

DMSO: 100mg/mL
Ethanol: 20mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for BRL50481, inhibitor

Home; Metabolism; PDE

Product References and Citations for BRL50481, inhibitor

1. Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurologicaland inflammatory disorders. Expert Opin Drug Discov. 2013 Jun;8 (6):733-51.
2. Smith SJ, et al. Discovery of BRL 50481 [3- (N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol. 2004 Dec;66 (6):1679-89.

Other Notes

Small volumes of BRL50481, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRL50481 purchase

MBS5751567 is an inhibitor targeting BRL50481. Also known as BRL 50481.