AZ304 Inhibitor

Name: AZ304 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751617
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751617

AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ304, Inhibitor

Full Product Name

AZ304

Product Gene Name

AZ304, inhibitor

Form/Format

Powder

Purity/Purification

99.83%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

451.52

Formula

C27H25N5O2

CAS

942507-42-8

Smiles

COc1ccc2c(Nc3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3C)ncnc2c1

Receptor (IC50)

B-RAF V600E: 38nM (cell free)
B-RAF: 79nM (cell free)
C-RAF: 68nM (cell free
p38: 6nM (cell free)
CSF1R: 35nM (cell free)

Solubility

DMSO: 85mg/mL
Ethanol: 4mg/mL
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for AZ304, inhibitor

Home; MAPK; Raf

Product References and Citations for AZ304, inhibitor

1. Ma R, et al. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018 May;118 (11):1453-1463.

Other Notes

Small volumes of AZ304, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZ304 purchase

MBS5751617 is an inhibitor targeting AZ304.