IACS-10759 Inhibitor

Name: IACS-10759 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751764
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751764

IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IACS-10759, Inhibitor

Full Product Name

IACS-10759

Product Gene Name

IACS-10759, inhibitor

Product Synonym Names

IACS10759; IACS 10759

Form/Format

Powder

Purity/Purification

99.83%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

562.56

Formula

C25H25F3N6O4S

CAS

1570496-34-2

Smiles

Cc1nc(nn1Cc1cccc(c1)N1CCC(CC1)S(C)(=O)=O)-c1nc(no1)-c1ccc(OC(F)(F)F)cc1

Receptor (IC50)

complex I of oxidative phosphorylation

Solubility

DMSO: 30mg/mL), 53.3mM
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for IACS-10759, inhibitor

Home; Others

Product References and Citations for IACS-10759, inhibitor

1. Vangapandu HV, et al. Biological and metabolic effects of IACS-2010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells. Oncotarget. 2018 May 18;9 (38):24980-241991.
2. Lissanu Deribe Y, et al. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 Jul;24 (7):1047-1057.
3. Molina JR, et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 Jul;24 (7):1036-1046.
4. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75 (15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380

Other Notes

Small volumes of IACS-10759, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IACS-10759 purchase

MBS5751764 is an inhibitor targeting IACS-10759.