BMS-687453 Inhibitor

BMS-687453 is a potent and selective PPAR alpha agonist, with an EC (50) of 10nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.

1. Li J, et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2- ((3- ((2- (4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl) (methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53 (7):2854-64.
2. Mukherjee R, Locke K T, Miao B, et al. Novel Peroxisome Proliferator-Activated Receptor Agonists Lower Low-Density Lipoprotein and Triglycerides, Raise High-Density Lipoprotein, and Synergistically Increase Cholesterol Excretion with a Liver X Receptor Agonist[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 327 (3):716-726.

Small volumes of BMS-687453, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751905 is an inhibitor targeting BMS-687453.