DT-061 Inhibitor

Name: DT-061 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752591
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752591

DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DT-061, Inhibitor

Full Product Name

DT-061

Product Gene Name

DT-061, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

520.52

Solubility

DMSO: 125mg/mL (240.14mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H23F3N2O5S

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@H]2[C@H](O)[C@@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O

CAS Number

1809427-19-7

Target & IC50

PP2A

In Vitro

DT-061 combined with AZD6244 is more significantly efficient. DT-061 (5mg/kg, oral gavage, 4 weeks) displays single-agent activity in inhibiting H358 or H441 xenograft growthours.

Product Categories/Family for DT-061, inhibitor

Phosphatase; Metabolic Enzyme/Protease; Others

Product References and Citations for DT-061, inhibitor

Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.
Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

Other Notes

Small volumes of DT-061, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DT-061 purchase

MBS5752591 is an inhibitor targeting DT-061.