Abemaciclib Metabolites M2 Inhibitor

Name: Abemaciclib Metabolites M2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752654
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752654

Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3nM) with anti-cancer activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Abemaciclib Metabolites M2, Inhibitor

Full Product Name

Abemaciclib Metabolites M2

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

478.54

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C25H28F2N8

SMILES

CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C

CAS Number

1231930-57-6

Target & IC50

CDK4: ic50 1-3nM
CDK6: ic50 1-3nM

Product Categories/Family for Abemaciclib Metabolites M2, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for Abemaciclib Metabolites M2, inhibitor

Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).
Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).

Other Notes

Small volumes of Abemaciclib Metabolites M2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Abemaciclib Metabolites M2 purchase

MBS5752654 is an inhibitor targeting Abemaciclib Metabolites M2.