Atuveciclib S-Enantiomer Inhibitor

Name: Atuveciclib S-Enantiomer Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752766
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752766

Atuveciclib (BAY-1143572) S-enantiomer is a potent and selective CDK9 inhibitor (IC50: 16nM for CDK9/CycT1). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Atuveciclib S-Enantiomer, Inhibitor

Full Product Name

Atuveciclib S-Enantiomer

Product Synonym Names

BAY-1143572 S-Enantiomer

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

387.43

Solubility

DMSO: 113mg/mL (291.67mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H18FN5O2S

SMILES

N=[S@@](CC1=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=CC=C1)(C)=O

Target & IC50

CDK9/CycT1: ic50 16nM

In Vitro

In comparison with Atuveciclib, Atuveciclib S-enantiomer reveals very similar in-vitro properties, well within the limits of measurement accuracy; however, with multiple batches of Atuveciclib S-enantiomer, there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC50: 16nM for CDK9/CycT1) and antiproliferative activity against HeLa cells (IC50: 1100nM).

Product Categories/Family for Atuveciclib S-Enantiomer, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for Atuveciclib S-Enantiomer, inhibitor

Lucking U, et al. Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the treatment,of Cancer. ChemMedChem. 2017 Nov 8;12(21):1776-1793.
Lucking U, et al. Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the treatment,of Cancer. ChemMedChem. 2017 Nov 8;12(21):1776-1793.

Other Notes

Small volumes of Atuveciclib S-Enantiomer, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Atuveciclib S-Enantiomer purchase

MBS5752766 is an inhibitor targeting Atuveciclib S-Enantiomer.