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EFNA3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9604669

Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EFNA3, Polyclonal Antibody
Full Product Name
EFNA3 Antibody
Product Gene Name
anti-EFNA3 antibody
Product Synonym Names
EFL 2; EFL-2; EFL2; EFN A3; EFNA 3; Efna3; EFNA3_HUMAN; EHK1 L; EHK1 ligand; EHK1-L; EHK1L; EPH related receptor tyrosine kinase ligand 3; EPH-related receptor tyrosine kinase ligand 3; Ephrin-A3; EphrinA3; EPLG 3; EPLG3; LERK 3; LERK-3; LERK3; Ligand of eph related kinase 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Peptide affinity purification
Concentration
1mg/ml (lot specific)
Specificity
EFNA3 antibody detects endogenous levels of total EFNA3
Preparation and Storage
Store at -20°C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
Ephrin A3 peptide (MBS9623386) is used for blocking the activity of Ephrin A3 antibody (MBS9604669)
Molecular Weight
38 kD
3D Structure
ModBase 3D Structure for P52797
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human Ephrin A3,corresponding to a region within C-terminal amino acids.
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EFNA3 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-EFNA3 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500
ELISA: 1:20000-1:40000

The optimal dilutions should be determined by the end user.

IMPORTANT: for western blots, incubate membrane with diluted Ab in 5% w/v milk, 1X TBS, 0.1% Tween® at 4°C with gentle shaking, overnight.

Immunofluorescence (IF) of anti-EFNA3 antibody

MBS9604669 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-EFNA3 Polyclonal Antibody – Cat# MBS9604669

Western Blot (WB) of anti-EFNA3 antibody

Western blot analysis of extracts from HepG2 cells using EFNA3 antibody.
Rabbit Anti-EFNA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9604669

Other Notes

Small volumes of anti-EFNA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EFNA3 purchase

MBS9604669 is an antibody targeting EFNA3. Also known as EFNA3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EFNA3. It may not necessarily be applicable to this product.

NCBI GI #
4826708
NCBI GeneID
1944
NCBI Accession #
NP_004943.1
UniProt Primary Accession #
P52797
UniProt Secondary Accession #
Q0VGC9; Q5SR70; B7ZAD3; D3DV85
UniProt Related Accession #
P52797
GenBank Nucleotide #
NM_004952.4
NCBI Official Full Name
ephrin-A3
NCBI Official Synonym Full Names
ephrin A3
NCBI Official Symbol
EFNA3
NCBI Official Synonym Symbols
EFL2; EPLG3; LERK3; Ehk1-L
UniProt Protein Name
Ephrin-A3
UniProt Synonym Protein Names
EFL-2; EHK1 ligand; EHK1-L; EPH-related receptor tyrosine kinase ligand 3; LERK-3
Protein Family
Ephrin
UniProt Gene Name
EFNA3
UniProt Synonym Gene Names
EFL2; EPLG3; LERK3; EHK1-L; LERK-3
NCBI Protein Information
ephrin-A3

NCBI Summary for EFNA3

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
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UniProt Comments for EFNA3

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling ().
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Research Articles on EFNA3

1. E2F3 and ephrin A3 are putative targets of miR-210, and their protein expression was up-regulated in the angiosarcoma cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EFNA3 antibody

 Reference Product  PubMed Publications
 EPHA4 antibody  >2 publications with EFNA3 and EPHA4
 EPHA7 antibody  >1 publications with EFNA3 and EPHA7
 EPHA5 antibody  >1 publications with EFNA3 and EPHA5
 EPHA2 antibody  >1 publications with EFNA3 and EPHA2

Pathways associated with anti-EFNA3 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-EFNA3 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with EFNA3 and Disease Models, Animal
 Brain Diseases Antibodies  >1 publications with EFNA3 and Brain Diseases
 Epilepsy Antibodies  >1 publications with EFNA3 and Epilepsy
 Congenital Abnormalities Antibodies  >1 publications with EFNA3 and Congenital Abnormalities
 Inflammation Antibodies  >1 publications with EFNA3 and Inflammation
 Nervous System Malformations Antibodies  >1 publications with EFNA3 and Nervous System Malformations
 Mental Disorders Antibodies  >1 publications with EFNA3 and Mental Disorders
 Seizures Antibodies  >1 publications with EFNA3 and Seizures
 Abnormalities, Multiple Antibodies  >1 publications with EFNA3 and Abnormalities, Multiple
 Cardiovascular Diseases Antibodies  >1 publications with EFNA3 and Cardiovascular Diseases

Organs/Tissues associated with anti-EFNA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with EFNA3 and Brain
 Liver Antibodies  >1 publications with EFNA3 and Liver
 Placenta Antibodies  >1 publications with EFNA3 and Placenta
 Skin Antibodies  >1 publications with EFNA3 and Skin
 Embryonic Tissue Antibodies  >1 publications with EFNA3 and Embryonic Tissue
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