BI-4020 Inhibitor

Name: BI-4020 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752794
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752794

BI-4020 is a fourth-generation, non-covalent, and orally active inhibitor of EGFR tyrosine kinase. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BI-4020, Inhibitor

Full Product Name

BI-4020

Product Gene Name

BI-4020, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

542.68

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C30H38N8O2

SMILES

O=C(C1=CC(C)=NC(C2=C(OCCC[C@@H](C)C3)N(C)N=C2)=C1)/N=C(N4)/N3C5=C4C=CC(CN6CCN(C)CC6)=C5

Target & IC50

EGFRdel19 T790M C797S: ic50 0.2nM
EGFRdel19: ic50 1nM
EGFRWT: ic50 190nM
EGFRdel19 T790M

In Vitro

In the human PC-9 (EGFR del19/T790M/C797S) triple mutant NSCLC xenograft model in mice, BI-4020 leads to tumor regressions.

Product Categories/Family for BI-4020, inhibitor

Angiogenesis; EGFR; JAK/STAT signaling; Tyrosine Kinase/Adaptors

Product References and Citations for BI-4020, inhibitor

Engelhardt H,et al. Start selective and rigidify: The discovery path towards a next generation of EGFR tyrosine kinase inhibitors. J Med Chem. 2019 Nov 5.
Engelhardt H,et al. Start selective and rigidify: The discovery path towards a next generation of EGFR tyrosine kinase inhibitors. J Med Chem. 2019 Nov 5.

Other Notes

Small volumes of BI-4020, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BI-4020 purchase

MBS5752794 is an inhibitor targeting BI-4020.