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BI-749327 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752795

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13nM, 19nM and 15nM for mouse, human and guinea pig TRPC6). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BI-749327, Inhibitor
Full Product Name
BI-749327
Product Gene Name
BI-749327, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
442.43
Solubility
DMSO: 31.25mg/mL (70.63mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H21F3N4O2
SMILES
NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1
CAS Number
2361241-23-6
Target & IC50
mouse TRPC6: ic50 13nM
human TRPC6: ic50 19nM
guinea pig TRPC6: ic50 15nM
In Vitro
BI-749327 (30mg/kg/day; i.g.) improves left heart function, reduces volume/mass ratio, and blunts expression of profibrotic genes and interstitial fibrosis in mice subjected to sustained pressure overload. BI-749327 dose-dependently reduces renal fibrosis and associated gene expression in mice with unilateral ureteral obstruction. BI-749327 (3-30mg/kg; p.o.) has a long terminal half-life (t1/2 8.5-13.5 hours) for mice.

Structure of BI-749327, inhibitor

BI-749327 Inhibitor – Cat# MBS5752795

Product References and Citations for BI-749327, inhibitor

Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161.
Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161.

Other Notes

Small volumes of BI-749327, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BI-749327 purchase

MBS5752795 is an inhibitor targeting BI-749327.
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