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BPN14770 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752816

BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8nM and 7.4nM for PDE4D7 and PDE4D3). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BPN14770, Inhibitor
Full Product Name
BPN14770
Product Gene Name
BPN14770, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
405.8
Solubility
DMSO: 260mg/mL (640.71mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H15ClF3NO2
SMILES
O=C(O)CC1=CC=C(CC2=CC(C3=CC=CC(Cl)=C3)=NC(C(F)(F)F)=C2)C=C1
CAS Number
1606974-33-7
Target & IC50
PDE4D3: ic50 7.4nM
PDE4D7: ic50 7.8nM
In Vitro
BPN14770 increases brain cAMP increases phosphorylation of CREB and increases the production of brain-derived neurotrophic factor (BDNF) in the hippocampus [1]. BPN14770 (0.1-30mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition at doses above 0.3mg/kg [2].

Product References and Citations for BPN14770, inhibitor

Ricciarelli R, et al. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment,of Alzheimer's disease. Sci Rep. 2017 Apr 12;7:46320.
Ricciarelli R, et al. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment,of Alzheimer's disease. Sci Rep. 2017 Apr 12;7:46320.
Gurney ME, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the treatment,of Fragile X Syndrome and Other Brain Disorders. J Med Chem. 2019 May 23;62(10):4884-4901.
Gurney ME, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the treatment,of Fragile X Syndrome and Other Brain Disorders. J Med Chem. 2019 May 23;62(10):4884-4901.

Other Notes

Small volumes of BPN14770, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BPN14770 purchase

MBS5752816 is an inhibitor targeting BPN14770.
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