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CNX-500 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752935

CNX-500 is a probe consisting of a covalent Btk inhibitor chemically linked to biotin. CNX-500 has inhibitory activity against Btk (IC50: 0.5nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase EGFR and upstream… More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNX-500, Inhibitor
Full Product Name
CNX-500
Product Gene Name
CNX-500, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
961.18
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C48H68N10O9S
SMILES
O=C(NCCCOCCOCCOCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)CCCC(NCCCOC3=CC=CC(NC4=NC=C(C)C(NC5=CC=CC(NC(C=C)=O)=C5)=N4)=C3)=O
CAS Number
1202758-21-1
Target & IC50
Others
In Vitro
In Ramos cells exposed to a range of CC-292 concentrations, the amount of Btk captured by the probe is compared with untreated samples and the extent of Btk bonded is demonstrated to be proportional to CC-292 drug concentration.

Product References and Citations for CNX-500, inhibitor

Evans EK, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28.

Other Notes

Small volumes of CNX-500, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNX-500 purchase

MBS5752935 is an inhibitor targeting CNX-500.
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