E6130 Inhibitor

Name: E6130 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753064
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753064

E6130 may be effective in the treatment,of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

E6130, Inhibitor

Full Product Name

E6130

Product Gene Name

E6130, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

556.06

Solubility

DMSO: 250mg/mL (449.59mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H37ClF3N3O3

SMILES

C[C@@H](C1)[C@@](C(NC2CCN(CC3=CCCCC3)CC2)=O)(CC(O)=O)CN1CC4=C(C(F)(F)F)C=CC=C4Cl

CAS Number

1427058-33-0

Target & IC50

CX3CR1

In Vitro

E6130(10 or 30mg /kg, p.o.) reduced some parameters associated with inflammatory bowel disease in a mouse model of CD4+ CD45RBhigh t cell metastatic colitis and a mouse model of oxazolidin-induced colitis.

Product Categories/Family for E6130, inhibitor

Autophagy; CXCR; GPCR/G Protein; Immunology/Inflammation

Product References and Citations for E6130, inhibitor

Wakita H, et al. E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis. Mol Pharmacol. 2017 Nov;92(5):502-509.
Wakita H, et al. E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis. Mol Pharmacol. 2017 Nov;92(5):502-509.

Other Notes

Small volumes of E6130, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for E6130 purchase

MBS5753064 is an inhibitor targeting E6130.