GFB-8438 Inhibitor

Name: GFB-8438 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753185
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753185

GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model.GFB-8438 is a potent and subtype… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GFB-8438, Inhibitor

Full Product Name

GFB-8438

Product Gene Name

GFB-8438, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

386.76

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C16H14ClF3N4O2

SMILES

FC(F)(F)C1=CC=CC=C1CN1CCN(CC1=O)C1=C(Cl)C(=O)NN=C1

CAS Number

2304549-73-1

Target & IC50

hTRPC5: ic50 0.18uM
hTRPC4: ic50 0.29uM
rTRPC5: ic50 0.18uM

Product Categories/Family for GFB-8438, inhibitor

Membrane transporter/Ion channel; TRP/TRPV Channel

Product References and Citations for GFB-8438, inhibitor

Yu M, et al.Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett. 2019 Oct 22;10(11):1579-1585.

Other Notes

Small volumes of GFB-8438, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GFB-8438 purchase

MBS5753185 is an inhibitor targeting GFB-8438.