GSK366 Inhibitor – GSK 366

Name: GSK366 Inhibitor; GSK 366; MyBioSource
Brand: MyBioSource
SKU: MBS5753230
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753230

GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7nM and 2.3nM for P. fluorescens-KMO and human KMO). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK 366 (GSK366), Inhibitor

Full Product Name

GSK 366

Product Gene Name

GSK366, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

361.78

Solubility

DMSO: 250mg/mL (691.03mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H16ClN3O4

SMILES

O=C(O)CCC1=NOC2=C1C=C(Cl)C(O[C@@H](C3=NN=C(C)C=C3)C)=C2

CAS Number

1953157-39-5

Target & IC50

human KMO: ic50 2.3nM
Pf-KMO: ic50 0.7nM

Product Categories/Family for GSK366, inhibitor

Metabolism; Hydroxylase

Product References and Citations for GSK366, inhibitor

Hutchinson JP, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.
Hutchinson JP, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.

Other Notes

Small volumes of GSK366, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK366 purchase

MBS5753230 is an inhibitor targeting GSK366. Also known as GSK 366.