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GSK2643943A Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753242

GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor (IC50: 160nM for USP20/Ub-Rho). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GSK2643943A, Inhibitor
Full Product Name
GSK2643943A
Product Gene Name
GSK2643943A, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
277.3
Solubility
DMSO: 125mg/mL (450.78mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H12FN3
SMILES
FC1=CC=CC(/C=C/C2=CC(NC(N)=C3C#N)=C3C=C2)=C1
Target & IC50
USP20/Ub-Rho: ic50 160nM

Structure of GSK2643943A, inhibitor

GSK2643943A Inhibitor – Cat# MBS5753242

Product References and Citations for GSK2643943A, inhibitor

Harrigan JA, et al.Deubiquitylating enzymes and drug discovery: emerging opportunities.Nat Rev Drug Discov. 2018 Jan;17(1):57-78.
Harrigan JA, et al.Deubiquitylating enzymes and drug discovery: emerging opportunities.Nat Rev Drug Discov. 2018 Jan;17(1):57-78.
Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer. Neoplasm. 2017 Dec.
Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer. Neoplasm. 2017 Dec.

Other Notes

Small volumes of GSK2643943A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK2643943A purchase

MBS5753242 is an inhibitor targeting GSK2643943A.
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