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MK0893 Inhibitor – Mk 0893

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753488

MBS5753488 is an inhibitor targeting MK0893. Also known as MK 0893. MK 0893 is a potent, selective antagonist of glucagon receptor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MK 0893 (MK0893), Inhibitor
Full Product Name
MK 0893
Product Gene Name
MK0893, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
588.48
Solubility
DMSO: 33.33mg/mL (56.64mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C32H27Cl2N3O4
SMILES
ClC1=CC(C2=NN(C(C3=CC4=C(C=C3)C=C(OC)C=C4)=C2)[C@H](C5=CC=C(C=C5)C(NCCC(O)=O)=O)C)=CC(Cl)=C1
CAS Number
870823-12-4
Target & IC50
glucagon receptor: ic50 6.6nM
In Vitro
In hGCGR mice on a high fat diet, MK 0893 at 3, and 10mpk po in feed lowers blood glucose levels by 89% and 94% at day 10, respectively, relative to the difference between the vehicle control and lean hGCGR mice[1].

Structure of MK0893, inhibitor

MK0893 Inhibitor – Cat# MBS5753488

Product References and Citations for MK0893, inhibitor

Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-beta-alanine (MK-0893) for the treatment,of type II diabetes.J Med Chem. 2012 Jul 12;
Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-beta-alanine (MK-0893) for the treatment,of type II diabetes.J Med Chem. 2012 Jul 12

Other Notes

Small volumes of MK0893, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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