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(RAC)-VU6008667 Inhibitor – (Rac)-Vu 6008667

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753801

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50 of 1.8 uM and pIC50 of 5.75, has high CNS penetration. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
(Rac)-VU 6008667 ((Rac)-VU6008667), Inhibitor
Full Product Name
(Rac)-VU 6008667
Product Gene Name
(Rac)-VU6008667, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
438.85
Solubility
DMSO: 125mg/mL (284.84mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H17ClF2N2O2
SMILES
O=C1N2C(N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C(C)=C4)C5=C1C=CC=C5
CAS Number
2092917-63-8
Target & IC50
M5: ic50 1.8uM

Structure of (Rac)-VU6008667, inhibitor

(RAC)-VU6008667 Inhibitor – Cat# MBS5753801

Product References and Citations for (Rac)-VU6008667, inhibitor

McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.
McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

Other Notes

Small volumes of (Rac)-VU6008667, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (Rac)-VU6008667 purchase

MBS5753801 is an inhibitor targeting (Rac)-VU6008667. Also known as (Rac)-VU 6008667.
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