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SHIN1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753906

SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) (IC50s: 5 and 13nM, respectively) in an in vitro assay. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SHIN1, Inhibitor
Full Product Name
SHIN1
Product Gene Name
SHIN1, inhibitor
Product Synonym Names
RZ-2994
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
400.47
Solubility
DMSO: 50mg/mL (124.85mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H24N4O2
SMILES
OCC1=CC(C2=CC=CC=C2)=CC(C3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1
CAS Number
2146095-85-2
Target & IC50
SHMT1: ic50 13nM
In Vitro
SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50: 10nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates [1].

Structure of SHIN1, inhibitor

SHIN1 Inhibitor – Cat# MBS5753906

Product References and Citations for SHIN1, inhibitor

Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

Other Notes

Small volumes of SHIN1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHIN1 purchase

MBS5753906 is an inhibitor targeting SHIN1.
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