SIAIS178 Inhibitor

Name: SIAIS178 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753911
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753911

SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SIAIS178, Inhibitor

Full Product Name

SIAIS178

Product Gene Name

SIAIS178, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

1012.68

Solubility

DMSO: 300mg/mL (296.24mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C50H62ClN11O6S2

SMILES

O=C(N1CCN(C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=C2)CC1)CCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O

CAS Number

2376047-73-1

Target & IC50

VHL: ic50 24nM
Bcr-Abl: ic50 24nM

In Vitro

Tumor progression in a dose-dependent manner attenuated by SIAIS178 (ip; 5, 15, and 45mg/kg; 12 days), as determined by serial volumetric measurement. SIAIS178 (iv or ip; 2mg/kg; 24 hours) has T1/2 of 3.82 and 12.35 hours and Cmax of 1165.2nM and 30nM for iv and ip, respectively.

Product Categories/Family for SIAIS178, inhibitor

PROTAC; Angiogenesis; Cytoskeletal Signaling

Product References and Citations for SIAIS178, inhibitor

Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.

Other Notes

Small volumes of SIAIS178, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIAIS178 purchase

MBS5753911 is an inhibitor targeting SIAIS178.