TAK-071 Inhibitor

Name: TAK-071 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753996
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753996

TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TAK-071, Inhibitor

Full Product Name

TAK-071

Product Gene Name

TAK-071, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

421.46

Solubility

DMSO: 134mg/mL (317.94mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H24FN3O3

SMILES

Cc1c(Cc2ccc(cc2)-n2cccn2)cc2C(=O)N(Cc2c1F)[C@H]1COCC[C@@H]1O

CAS Number

1820812-16-5

Target & IC50

M1R: ic50 520nM (EC50)

In Vitro

In rats, TAK-071(0.3mg/kg) increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits, TAK-071(10mg/kg) also induce diarrhea.

Product Categories/Family for TAK-071, inhibitor

Neuroscience

Product References and Citations for TAK-071, inhibitor

Sako Y, et al. TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects. Neuropsychopharmacology. 2018 Aug doi: 10.1038/s41386-018-0168-8.

Other Notes

Small volumes of TAK-071, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAK-071 purchase

MBS5753996 is an inhibitor targeting TAK-071.