THK5351 Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

327.35

DMSO: 50mg/mL (152.74mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

C18H18FN3O2

O[C@@H](COC1=CC=C2N=C(C3=CC=C(NC)N=C3)C=CC2=C1)CF

1707147-26-9

Others

In mice,THK5351 exhibits favorable pharmacokinetics and no defluorination. 18F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1mg/kg, no animals died and no treatment,related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination[1]. [3H]THK-5351 binding to tau deposits with a high selectivity. In the temporal cortex, although patients with PSP exhibits no remarkable [18F]THK-5351 retention, significantly higher tracer retention is observed in the globus pallidus and midbrain[2].