AG1433 Inhibitor – Tyrphostin

Name: AG1433 Inhibitor; Tyrphostin; MyBioSource
Brand: MyBioSource
SKU: MBS5754076
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754076

Tyrphostin AG1433 (SU1433) is an inhibitor of tyrosine kinases, and also a selective PDGFRbeta and VEGFR-2 (Flk-1/KDR) inhibitor (IC50s: 5.0uM and 9.3uM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tyrphostin AG1433, Inhibitor

Full Product Name

Tyrphostin AG1433

Product Gene Name

AG1433, inhibitor

Product Synonym Names

SU1433; AG1433

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

266.29

Solubility

DMSO: 62.5mg/mL (234.71mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H14N2O2

SMILES

OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O

CAS Number

168835-90-3

Target & IC50

Flk-1: ic50 9.3uM
PDGFRbeta: ic50 5uM

In Vitro

Tyrphostin AG1433 is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos, and prevents the formation of new yessels under the pellets[2].

Product Categories/Family for AG1433, inhibitor

Angiogenesis; PDGFR

Product References and Citations for AG1433, inhibitor

Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33.
Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33.
Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5.
Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5.
Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62.
Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62.
Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7.
Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7.

Other Notes

Small volumes of AG1433, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AG1433 purchase

MBS5754076 is an inhibitor targeting AG1433. Also known as Tyrphostin AG1433.