YKL-5-124 Inhibitor – TFA

Name: YKL-5-124 Inhibitor; TFA; MyBioSource
Brand: MyBioSource
SKU: MBS5754140
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754140

YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5nM and 9.7nM for CDK7 and CDK7/Mat1/CycH, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

YKL-5-124 TFA, Inhibitor

Full Product Name

YKL-5-124 TFA

Product Gene Name

YKL-5-124, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

629.63

Solubility

DMSO: 100mg/mL (158.82mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C30H34F3N7O5

SMILES

CC1(C)N(C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)CC3=C1NN=C3NC(C4=CC=C(NC(C=C)=O)C=C4)=O.FC(F)(C(O)=O)F

Target & IC50

CDK7: ic50 53.5nM
CDK7/Mat1/CycH: ic50 9.7nM
CDK2: ic50 1300nM
CDK9: ic50 3020nM

In Vitro

In G1- and G2/M-phase cells and a corresponding loss of S-phase cells, YKL-5-124 (0-2000nM; 72 hours; HAP1 cells) treatment, causes a dose-dependent increase. YKL-5-124 (0-2000nM; 24 hours; HAP1 WT cells) treatment, inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion.

Product Categories/Family for YKL-5-124, inhibitor

Cell Cycle/Checkpoint

Product References and Citations for YKL-5-124, inhibitor

Olson CM, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.

Other Notes

Small volumes of YKL-5-124, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YKL-5-124 purchase

MBS5754140 is an inhibitor targeting YKL-5-124. Also known as YKL-5-124 TFA.