Zamicastat Inhibitor

Name: Zamicastat Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754150
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754150

Zamicastat is an inhibitor of dopamine beta-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8uM and 17.0uM, respectively). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Zamicastat, Inhibitor

Full Product Name

Zamicastat

Product Synonym Names

BIA 5-1058

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

401.47

Solubility

DMSO: 150mg/mL (373.63mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H21F2N3OS

SMILES

S=C1N([C@@H]2CC3=CC(F)=CC(F)=C3OC2)C(CCNCC4=CC=CC=C4)=CN1

CAS Number

1080028-80-3

Target & IC50

Dopamine beta-hydroxylase: ic50 73.8?uM
P-gp: ic50 17.0?uM
BCRP

In Vitro

In the Dahl SS rat, Zamicastat (10, 30 and 100mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2].

Product Categories/Family for Zamicastat, inhibitor

GPCR/G Protein; Neuroscience

Product References and Citations for Zamicastat, inhibitor

Bicker J, et al. In vitro assessment of the interactions of dopamine beta-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein. Eur J Pharm Sci. 2018 May 30;117:35-40.
Bicker J, et al. In vitro assessment of the interactions of dopamine beta-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein. Eur J Pharm Sci. 2018 May 30;117:35-40.
Igreja B, et al. Effects of Zamicastat treatment,in a genetic model of salt-sensitive hypertension and heart failure. Eur J Pharmacol. 2019 Jan 5;842:125-132.
Igreja B, et al. Effects of Zamicastat treatment,in a genetic model of salt-sensitive hypertension and heart failure. Eur J Pharmacol. 2019 Jan 5;842:125-132.

Other Notes

Small volumes of Zamicastat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Zamicastat purchase

MBS5754150 is an inhibitor targeting Zamicastat.