AZ7550 Inhibitor – Mesylate

Name: AZ7550 Inhibitor; Mesylate; MyBioSource
Brand: MyBioSource
SKU: MBS5754248
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754248

AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6uM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ7550 Mesylate, Inhibitor

Full Product Name

AZ7550 Mesylate

Product Gene Name

AZ7550, inhibitor

Product Synonym Names

AZ7550 trimesylate salt

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

773.9

Solubility

DMSO: 25mg/mL (32.30mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C30H43N7O11S3

SMILES

CN1C=C(C2=NC(NC3=CC(NC(C=C)=O)=C(N(CCNC)C)C=C3OC)=NC=C2)C4=CC=CC=C41.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O

Target & IC50

IGF1R: ic50 1.6uM
MLK1: ic50 88nM
ACK1: ic50 156nM
ErbB4: ic50 195nM
MNK2: ic50 228nM
FLT3: ic50 302nM
ALK: ic50 420nM
FES: ic50 449nM
IRR: ic50 840nM
BRK: ic50 843nM
BLK: ic50 977nM
FAK: ic50 995nM
Ins R: ic50 1256nM
TEC: ic50 1317nM
FLT4: ic50 1784nM
PYK2: ic50 2288nM

In Vitro

AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537nM).

Product Categories/Family for AZ7550, inhibitor

MAPK; MLK

Product References and Citations for AZ7550, inhibitor

Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.
Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

Other Notes

Small volumes of AZ7550, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZ7550 purchase

MBS5754248 is an inhibitor targeting AZ7550. Also known as AZ7550 Mesylate.