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K-RAS Inhibitor – Degrader-1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754372

MBS5754372 is an inhibitor targeting K-Ras. Also known as PROTAC K-Ras Degrader-1. PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC. More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
K-Ras Degrader-1, Inhibitor
Full Product Name
PROTAC K-Ras Degrader-1
Product Gene Name
K-Ras, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
999.12
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C53H62N10O10
SMILES
CN1[C@@H](C[C@@H](OCCOCCOCCOCCNC2=C3C(C(N(C4C(NC(CC4)=O)=O)C3=O)=O)=CC=C2)C1)COC5=NC(N6C[C@@H](N(C(C=C)=O)CC6)CC#N)=C7C(CN(C8=CC=CC9=C8C=CC=C9)CC7)=N5
CAS Number
2378258-52-5
Target & IC50
KRAS G12C

Product Categories/Family for K-Ras, inhibitor

MAPK; Ras

Structure of K-Ras, inhibitor

K-RAS Inhibitor – Cat# MBS5754372

Product References and Citations for K-Ras, inhibitor

CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Other Notes

Small volumes of K-Ras, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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