4-P-PDOT Inhibitor

Name: 4-P-PDOT Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754435
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754435

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist, which significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity)[1][2][3][4], and it… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

4-P-PDOT, Inhibitor

Full Product Name

4-P-PDOT

Product Gene Name

4-P-PDOT, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

279.38

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H21NO

SMILES

CCC(NC1CC2=C(C=CC=C2)C(C3=CC=CC=C3)C1)=O

CAS Number

134865-74-0

Target & IC50

MT2 receptor

In Vitro

4-P-PDOT (0.5-1.0mg/kg; intravenous injection; klotho mutant mice) treatment,significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2]. 4-P-PDOT treatment,significantly reverses the memory function of Melatonin-treated klotho mutant mice.

Product Categories/Family for 4-P-PDOT, inhibitor

GPCR/G Protein; Neuronal Signaling

Product References and Citations for 4-P-PDOT, inhibitor

Dubocovich ML. Melatonin receptors: are there multiple subtypes, Trends Pharmacol Sci. 1995 Feb;16(2):50-6.
Dubocovich ML. Melatonin receptors: are there multiple subtypes, Trends Pharmacol Sci. 1995 Feb;16(2):50-6.
hin EJ, et al. Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int J Neuropsychopharmacol. 2014 Dec 30;18(6). pii: pyu105.
hin EJ, et al. Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int J Neuropsychopharmacol. 2014 Dec 30;18(6). pii: pyu105.
Christopher Browning, et al. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. British Journal of Pharmacology (2000) 129, 877-886.
Christopher Browning, et al. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. British Journal of Pharmacology (2000) 129, 877-886.
Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75.
Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75.

Other Notes

Small volumes of 4-P-PDOT, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 4-P-PDOT purchase

MBS5754435 is an inhibitor targeting 4-P-PDOT.