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anti-CD136 (RON) antibody :: Rabbit CD136 (RON) Polyclonal Antibody

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Catalog # MBS462021
Unit / Price
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  0.1 mg  /  $265 +1 FREE 8GB USB
Testing Data
Product Name

CD136 (RON), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti CD136 antibody

Product Synonym Names
Rabbit anti-CD136; Recepteur dÂ’origine nantais (RON); Macrophage-Stimulating 1 Receptor (MST1R).
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Specificity
This antibody recognizes ~175 kDa of human LRP5 protein. It also reacts with mouse and rat. The other species are not tested.
Purity/Purification
The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
Form/Format
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
Concentration
Size: 100 ug/200 ul (lot specific)
Antigen Preparation
A synthetic peptide corresponding to the human CD136 at internal domain. This sequence is identical to mouse or rat origin.
Positive Control
CD136 transfected HEK293
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycle
Other Notes
Small volumes of anti-CD136 (RON) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD136 (RON) antibody
CD136, a transmembrane receptor tyrosine kinase, also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d'origine nantais), is a member of the MET proto-oncogene family (63% homology), and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition, CD136 contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. RON mediates multiple signaling cascades, such as MAPK, PI3K/AKT, FAK pathways. CD136 activation can also significantly increase C-Src activity. CD136 is a disulfide-linked 180kD heterodimer composed of a 35kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. CD136 is thought to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon.
Applications Tested/Suitable for anti-CD136 (RON) antibody
ELISA, Western Blot, Immunohistochemistry
Application Notes for anti-CD136 (RON) antibody
Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 2-5 ug/ml

anti-CD136 (RON) antibody Testing Data image
Molecular Weight
185 kDa
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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