AKR1C1-IN-1 Inhibitor

Name: AKR1C1-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754491
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754491

AKR1C1-IN-1 is a human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4nM for AKR1C1). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AKR1C1-IN-1, Inhibitor

Full Product Name

AKR1C1-IN-1

Product Gene Name

AKR1C1-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

99.44%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

293.11

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C13H9BrO3

SMILES

O=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O

CAS Number

4906-68-7

Target & IC50

AKR1C1: ic50 4nM (ki)
AKR1C2: ic50 87nM (ki)
AKR1C3: ic50 4.2uM (ki)
AKR1C4: ic50 18.2uM (ki)

In Vitro

AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460nM).

Product Categories/Family for AKR1C1-IN-1, inhibitor

Metabolism; NADPH

Product References and Citations for AKR1C1-IN-1, inhibitor

El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.
El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.

Other Notes

Small volumes of AKR1C1-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1C1-IN-1 purchase

MBS5754491 is an inhibitor targeting AKR1C1-IN-1.