Apratastat Inhibitor

Name: Apratastat Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754527
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754527

Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-alpha converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-alpha in vitro, ex vivo, and in vivo with… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Apratastat, Inhibitor

Full Product Name

Apratastat

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

414.5

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C17H22N2O6S2

SMILES

CC1(C)[C@H](C(NO)=O)N(S(=O)(C2=CC=C(OCC#CCO)C=C2)=O)CCS1

CAS Number

287405-51-0

Target & IC50

MMP
TNF-alpha

Product Categories/Family for Apratastat, inhibitor

Proteases/Proteasome; MMP; Apoptosis

Product References and Citations for Apratastat, inhibitor

Shu C, et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. J Clin Pharmacol. 2011 Apr;51(4):472-81.
Shu C, et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. J Clin Pharmacol. 2011 Apr;51(4):472-81.

Other Notes

Small volumes of Apratastat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Apratastat purchase

MBS5754527 is an inhibitor targeting Apratastat.