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BI689648 Inhibitor – Bi 689648

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754620

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1nM, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BI 689648 (BI689648), Inhibitor
Full Product Name
BI 689648
Product Gene Name
BI689648, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
298.34
Solubility
DMSO: 30mg/mL (100.56mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C16H18N4O2
SMILES
O=C(N1CCCC2=C1N=CC(C3=CC(COC)=CN=C3)=C2)N
CAS Number
1633009-87-6
Target & IC50
CYP11B1: ic50 310nM
CYP11B2: ic50 2.1nM
In Vitro
Compare with the FADs and LCI699, BI 689648 is highly selective in vitro, providing an IC50 for CYP11B2 of 2.1nM and a selectivity factor of 149 over CYP11B1. FAD286, by comparison, shows a similar IC50 for CYP11B2 (2.5nM). However, its greater potency against CYP11B1 (94nM) results in a comparatively modest selectivity factor of 38, approximately 4-fold less than BI 689648[1].

Structure of BI689648, inhibitor

BI689648 Inhibitor – Cat# MBS5754620

Product References and Citations for BI689648, inhibitor

Weldon SM, et al. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50.
Weldon SM, et al. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50.

Other Notes

Small volumes of BI689648, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BI689648 purchase

MBS5754620 is an inhibitor targeting BI689648. Also known as BI 689648.
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