CCT-251921 Inhibitor

Name: CCT-251921 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754682
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754682

CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCT-251921, Inhibitor

Full Product Name

CCT-251921

Product Gene Name

CCT-251921, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

410.9

Solubility

DMSO: 33.33mg/mL (81.11mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H23ClN6O

SMILES

Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CCNC2=O)CC1

CAS Number

1607837-31-9

Target & IC50

CDK8: ic50 2.3nM
CDK19: ic50 2.6nM

In Vitro

CCT-251921 shows improved oral pharmacokinetics and pharmaceutical properties. The inhibition of STAT1SER727 phosphorylation is maintained for more than 6 h after the last dose. In APC-mutant SW620 human colorectal carcinoma xenograft model, CCT-251921 treatment,reduces mice tumor weight (54.2%) on day 15.

Product Categories/Family for CCT-251921, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for CCT-251921, inhibitor

Mallinger A, et al. Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J Med Chem. 2016 Feb 11;59(3):1078-10
Mallinger A, et al. Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J Med Chem. 2016 Feb 11;59(3):1078-101.

Other Notes

Small volumes of CCT-251921, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCT-251921 purchase

MBS5754682 is an inhibitor targeting CCT-251921.