CDK9-IN-2 Inhibitor

Name: CDK9-IN-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754691
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754691

CDK9-IN-2 is a special CDK9 inhibitor extracted from patent WO/2012131594A1 (compound CDKI(8)) and has an IC50 of 5nM and 7nM in A2058 skin cell line (72 hours) and H929 multiple myeloma cell line (72 hours), respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDK9-IN-2, Inhibitor

Full Product Name

CDK9-IN-2

Product Gene Name

CDK9-IN-2, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

425.93

Solubility

DMSO: 50mg/mL (117.39mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H25ClFN5

SMILES

N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1

CAS Number

1263369-28-3

Target & IC50

CDK9: ic50 5nM
H929 multiple myeloma cell line

In Vitro

CDK9-IN-2 (200nM) reduces the expression of MEPCE indicating that MEPCE is a pharmacodynamic marker for any CDK9 inhibitor. The expression of MCL1 protein is reduced 2 hours after treatment, and it is further reduced after 16-hour exposure to CDK9-IN-2 (500nM).

Product Categories/Family for CDK9-IN-2, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for CDK9-IN-2, inhibitor

Michel Faure, et al. Pharmacodynamic markers associated with cyclin-dependent kinase inhibitors. From PCT Int. Appl. (2012), WO 2012131594A
Michel Faure, et al. Pharmacodynamic markers associated with cyclin-dependent kinase inhibitors. From PCT Int. Appl. (2012), WO 2012131594A1.

Other Notes

Small volumes of CDK9-IN-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK9-IN-2 purchase

MBS5754691 is an inhibitor targeting CDK9-IN-2.