Hematein Inhibitor

Name: Hematein Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754952
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754952

Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hematein, Inhibitor

Full Product Name

Hematein

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

300.26

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C16H12O6

SMILES

O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O

CAS Number

475-25-2

Target & IC50

CKII: ic50 0.74uM

In Vitro

In A427 lung cancer cell xenografts, Hematein (intraperitoneal injections; 50mg/kg; twice a week for 6 weeks) inhibits tumor growth[1].

Product Categories/Family for Hematein, inhibitor

Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells

Product References and Citations for Hematein, inhibitor

Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169.
Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169.
Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel. Int J Oncol. 2013 Nov;43(5):1517-22.
Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel. Int J Oncol. 2013 Nov;43(5):1517-22.

Other Notes

Small volumes of Hematein, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hematein purchase

MBS5754952 is an inhibitor targeting Hematein.